The following 2010 FIFA World Cup games were hosted at the Mbombela Stadium.

16 June 2010 Honduras  vs Chile Result: Honduras 0 , Chile 1
20 June 2010 Italy vs New Zeeland Result: Italy 1 , New Zeeland 1
23 June 2010 Australia vs Serbia Result: Australia 2, Serbia 1
25 June 2010 Korea DPR vs Côte d ‘ Ivoire Result: Korea DPR 0, Côte d ‘ Ivoire 3